A major conference focusing on improving acquisition and performance of Defense programs and systems, including network centric operations and data/information interoperability, systems engineering and all aspects of system sustainment, will be convened in San Diego, CA, October 25-28, 2010. This conference is sponsored by the National Defense Industrial Association, Systems Engineering Division, with technical co-sponsorship by IEEE AES, IEEE Systems Council and the International Council on Systems Engineering, and is supported by the Office of Under Secretary of Defense for Acquisition, Technology and Logistics, Direcotr, Systems and Software Engineering, and the Office of the DoD Chief Information Officer.